Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Clopidogrel Hydrogen Sulfate (Form II) in Different Solvents

Song, L.[Liangcheng], Li, M.[Minxu], Gong, J.[Junbo]
J. Chem. Eng. Data 2010, 55, 9, 4016-4018
ABSTRACT
As an urgent need in the design and upscale of the industrial crystallization process, solubilities of clopidogrel hydrogen sulfate (Form II) in ethanol, propanol, isopropanol, butanol, and acetone were measured using a laser-monitoring technique at temperatures ranging from (278.15 to 318.15) K. The experimental data were fitted well by the modified Apelblat equation.
Compounds
# Formula Name
1 C2H6O ethanol
2 C3H8O propan-1-ol
3 C3H8O propan-2-ol
4 C4H10O butan-1-ol
5 C3H6O acetone
6 C16H18ClNO6S2 (S)-(+)-Clopidogrel hydrogen sulfate
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 6
  • Triple point temperature, K ; Crystal 2
  • Crystal 2
  • Liquid
  • Gas
  • DSC
  • 1
  • POMD
  • 1
  • 6
  • Mole fraction - 6 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal 2 - 6
  • Titration method
  • 9
  • POMD
  • 2
  • 6
  • Mole fraction - 6 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal 2 - 6
  • Titration method
  • 9
  • POMD
  • 3
  • 6
  • Mole fraction - 6 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal 2 - 6
  • Titration method
  • 9
  • POMD
  • 4
  • 6
  • Mole fraction - 6 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal 2 - 6
  • Titration method
  • 9
  • POMD
  • 5
  • 6
  • Mole fraction - 6 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal 2 - 6
  • Titration method
  • 9