Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Felodipine and Nitrendipine in Liquid and Supercritical Carbon Dioxide by Cloud Point and UV Spectroscopy

Weinstein, R. D.[Randy D.], Hanlon, W. H.[William H.], Donohue, J. P., Simeone, M.[Michael], Rozich, A.[Anton], Muske, K. R.[Kenneth R.]
J. Chem. Eng. Data 2007, 52, 1, 256-260
ABSTRACT
The solubility of two calcium channel blockers, felodipine and nitrendipine, was measured in liquid and supercritical carbon dioxide at (298, 308, and 318) K and at pressures between (80 and 250) bar. The solubilites were measured experimentally through two methods: cloud point measurements and UV absorption. At lower pressures, and hence densities, the UV method was more accurate while at higher pressures and densities the solubilities measured by both methods were basically identical. Both of these compounds showed an increase in solubility with increasing temperature and density. The experimentally determined solubility was accurately modeled using an equation, derived from association laws, which had a strong solvent density and temperature dependence.
Compounds
# Formula Name
1 CO2 carbon dioxide
2 C18H20N2O6 nitrendipine
3 C18H19Cl2NO4 felodipine
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 3
  • Mole fraction - 3 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • visual observation of could point with volume change
  • 24
  • POMD
  • 1
  • 3
  • Mole fraction - 3 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • UV absorption
  • 18
  • POMD
  • 1
  • 2
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • visual observation of could point with volume change
  • 24
  • POMD
  • 1
  • 2
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • UV absorption
  • 18