The solubility of salicylic acid has been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate from (10 to 50) deg C. No new polymorphs or solvates of salicylic acid were found. The melting properties of salicylic acid were determined by differential scanning calorimetry. A correlation was observed between the solubility and the van t Hoff enthalpy of solution. A higher solubility was related to a lower van t Hoff enthalpy of solution. Water differed from the organic solvents in terms of solubility and its correlation to the van t Hoff enthalpy of solution. In addition, the morphology of salicylic acid crystals recrystallized from water differed from the other solvents.
Compounds
#
Formula
Name
1
C7H6O3
2-hydroxybenzoic acid
2
CH4O
methanol
3
C2H3N
acetonitrile
4
C2H4O2
acetic acid
5
C3H6O
acetone
6
C4H8O2
ethyl acetate
7
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
Molar enthalpy of transition or fusion, kJ/mol ; Crystal