ABSTRACT

Solubility equilibria of threonine in water/ethanol mixtures were measured in the temperature range between (10 and 46) deg C. Threonine exhibits good solubility in water and is hardly soluble in ethanol. The ternary-phase diagram of the threonine enantiomers in the solvents used reveals the presence of a conglomerate-forming system. Threonine shows ideal solution behavior (i.e., heterochiral interactions do not occur in solution). To correlate the measured data with regard to temperature and solvent composition, a simple empirical approach is proposed. The correlation presented is of interest for calculation of solubilities when designing crystallization or chromatography-based processes to separate the threonine enantiomers.

Compounds

#	Formula	Name
1	C4H9NO3	L-threonine
2	H2O	water
3	C2H6O	ethanol
4	C4H9NO3	DL-threonine

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Mass fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetry	8
POMD	1 2	Mass fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	HPLC	4
POMD	4 2	Mass fraction - 4 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	gravimetry	9
POMD	4 2	Mass fraction - 4 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	HPLC	4
POMD	3 1 2	Mass fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Volume ratio of component to other component of binary solvent - 2; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetry	12
POMD	3 1 2	Mass fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Volume ratio of component to other component of binary solvent - 2; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	HPLC	12
POMD	3 4 2	Mass fraction - 4 ; Liquid	Temperature, K; Liquid Solvent: Volume ratio of component to other component of binary solvent - 2; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	gravimetry	15
POMD	3 4 2	Mass fraction - 4 ; Liquid	Temperature, K; Liquid Solvent: Volume ratio of component to other component of binary solvent - 2; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	HPLC	10

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Chiral Threonine Species in Water/Ethanol Mixtures

Sapoundjiev, D.[Dragomir], Lorenz, H.[Heike], Seidel-Morgenstern, A.[Andreas]

ABSTRACT