Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Erythromycin A Dihydrate in Different Pure Solvents and Acetone + Water Binary Mixtures between 293 K and 323 K

Wang, Z.[Zhaohui], Wang, J.-K.[Jing-Kang], Zhang, M.-J.[Mei-Jing], Dang, L.[Leping]
J. Chem. Eng. Data 2006, 51, 3, 1062-1065
ABSTRACT
The solubility of erythromycin A dihydrate in pure ethanol, propan-2-ol, methanol, acetone, chloroform, and acetone + water was measured by a synthetic method at temperature ranging from 293.20 K to 323.00 K at atmosphere pressure. The laser monitoring observation technique was used to determine the disappearance of the solid phase in a solid + liquid mixture. The results of these measurements were correlated by a semiempirical Apelblat equation.
Compounds
# Formula Name
1 C37H71NO15 erythromycin A dihydrate
2 C2H6O ethanol
3 C3H8O propan-2-ol
4 CH4O methanol
5 C3H6O acetone
6 CHCl3 trichloromethane
7 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 5
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 6
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 7
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 7
  • POMD
  • 5
  • 7
  • 1
  • Mole fraction - 5 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 7; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Last crystal disappearance monitored with laser intensity
  • 63