This study investigated the solubilization of valdecoxib in aqueous solutions of glycerol, propylene glycol, and poly(ethylene glycol) 400 at (298.15, 303.15, and 308.15) K. The analysis of valdecoxib was carried out by UV spectral measurements at imax of 204 nm. The solubility of valdecoxib increased with increasing mass fraction of glycerol, propylene glycol, and poly(ethylene glycol) 400 at (298.15, 303.15, and 308.15) K. For poly(ethylene glycol) 400 + water mixtures, the solubility of valdecoxib was higher when compared to the glycerol + water and propylene glycol + water mixtures. The solubilization power of glycerol, propylene glycol, and poly(ethylene glycol) 400 at (298.15, 303.15, and 308.15) K was 1.1, 1.5, and 1.8; 2.6, 2.8, and 2.9; and 3.0, 3.5, and 3.9, respectively.
Compounds
#
Formula
Name
1
H2O
water
2
C3H8O3
glycerol
3
C3H8O2
1,2-propanediol
4
C16H14N2O3S
valdecoxib
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.