Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Lovastatin in Acetone, Methanol, Ethanol, Ethyl Acetate, and Butyl Acetate between 283 K and 323 K

Sun, H.[Hua], Gong, J.-b.[Jun-bo], Wang, J.-K.[Jing-Kang]
J. Chem. Eng. Data 2005, 50, 4, 1389-1391
ABSTRACT
The solubilities of lovastatin in acetone, methanol, ethanol, ethyl acetate, and butyl acetate between 283 K and 323 K were measured using a synthetic method. A laser monitoring observation technique was used to determine the disappearance of the solid phase in a solid + liquid mixture. The experimental solubility data was correlated with an empirical equation.
Compounds
# Formula Name
1 C24H36O5 lovastatin
2 C3H6O acetone
3 CH4O methanol
4 C2H6O ethanol
5 C4H8O2 ethyl acetate
6 C6H12O2 butyl ethanoate
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Phase equilibration
  • 10
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Phase equilibration
  • 10
  • POMD
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Phase equilibration
  • 10
  • POMD
  • 5
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Phase equilibration
  • 10
  • POMD
  • 6
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Phase equilibration
  • 10