Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Aspirin in Supercritical Carbon Dioxide with and without Acetone

Huang, Z.[Zaifu], Lu, W. D.[Wei D.], Kawi, S.[Sibudjing], Chiew, Y. C.[Yee C.]
J. Chem. Eng. Data 2004, 49, 5, 1323-1327
ABSTRACT
The equilibrium solubility of aspirin in supercritical CO2 has been determined using a dynamic method. Measurements were performed at pressures ranging from (10 to 25) MPa and temperatures from (308.15 to 328.15) K. The effect of a polar cosolvent, acetone, on the solubility of aspirin in supercritical carbon dioxide was also studied. The results show that the addition of acetone produces up to a 5-fold increase in the aspirin solubility. The solubility of aspirin in CO2 is well described by the Peng-Robinson equation of state and density based correlations over the pressure and temperature ranges studied.
Compounds
# Formula Name
1 C3H6O acetone
2 CO2 carbon dioxide
3 C9H8O4 2-acetoxybenzoic acid
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 2
  • Mole fraction - 3 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • OTHER
  • 24
  • POMD
  • 3
  • 1
  • 2
  • Mole fraction - 3 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Solvent: Mole fraction - 1; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • OTHER
  • 10