ABSTRACT

Equilibrium solubilities of five recently synthesized nifedipine analogues were measured at temperatures ranging from (328 to 348) K for bis(cyclohexyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol- 2-yl)-3,5-pyridinedicarboxylates (NP1) and bis(cyclohexylmethyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl- 5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylates (NP2) and (338 to 358) K for bis(2-cyclohexylethyl)- 1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylates (NP3), bis(3-cyclohexylpropyl)- 1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylates (NP4), and bis(4-cyclohexylbutyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylates (NP5) and in a pressure range from (12.2 to 35.5) MPa in supercritical carbon dioxide. The data were obtained by using a simple static sampling apparatus, which was tested by measuring the solubility of naphthalene in supercritical carbon dioxide. The measured solubilities were correlated using a semiempirical model. The calculated results show satisfactory agreement with the experimental data.

Compounds

#	Formula	Name
1	C25H34N4O6	bis(cyclohexyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylate
2	C27H38N4O6	bis(cyclohexylmethyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylate
3	C29H42N4O6	bis(2-cyclohexylethyl)-1,4-dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)-3,5-pyridinedicarboxylate
4	C31H46N4O6	bis(3-cyclohexylpropyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
5	C33H50N4O6	bis(4-cyclohexylbutyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
6	CO2	carbon dioxide

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	spectrophotometer	24
POMD	6 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 2	spectrophotometer	23
POMD	6 3	Mole fraction - 3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 3	spectrophotometer	27
POMD	6 4	Mole fraction - 4 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 4	spectrophotometer	21
POMD	6 5	Mole fraction - 5 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 5	spectrophotometer	21

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of Some Cyclohexyl Derivatives of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)- 3,5-pyridinedicarboxylates (Nifedipine Analogues) in Supercritical Carbon Dioxide. Part I

Khajeh, M.[Mostafa], Yamini, Y.[Yadollah], Miri, R.[Ramin], Hemmateenejad, B.[Bahram]

ABSTRACT