Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Acetazolamide in Supercritical Carbon Dioxide in the Presence of Ethanol as a Cosolvent

Duarte, A. R. C.[Ana Rita C.], Santiago, S.[Susana], de Sousa, H. C.[Herminio C.], Duarte, C. M. M.[Catarina M. M]
J. Chem. Eng. Data 2005, 50, 1, 216-220
ABSTRACT
Equilibrium solubility of acetazolamide, a carbonic-anhydrase inhibitor, in supercritical carbon dioxide in the presence of a cosolvent was measured by a static analytical method for three mole fractions of ethanol (5, 7.5, and 10) % at 313.0 K from (13.0 to 21.0) MPa and at 323.0 K from (13.0 to 21.0) MPa for a mole fraction of 5% ethanol The presence of a cosolvent (ethanol) was essential for the solubilization of the bioactive compound in supercritical carbon dioxide. The results obtained are useful for the design of supercritical processes with this drug. Experimental solubility data were correlated with two enhanced density-based models (Chrastil, I. Solubility of Solids in Supercritical Gases. J. Phys. Chem. 1982, 86, 3016-3021; Santiago, J. M.; Teja, A. S. The solubility of solids in supercritical fluids. Fluid Phase Equilib. 1999, 158-160, 501-510).
Compounds
# Formula Name
1 C4H6N4O3S2 5-acetamido-1,3,4-thiadiazole-2-sulphonamide
2 C2H6O ethanol
3 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 2
  • 3
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Solvent: Mole fraction - 2; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • analyzed by UV spectrophotometry after capture in a trap
  • 16