ABSTRACT

Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of six 1,4-dihydropyridine derivatives in supercritical carbon dioxide were reported at temperatures from (338 to 358) K and in the pressure range of (12.2 to 35.5) MPa. Results showed that solubilities increase linearly with increasing density at constant temperature and increase with increasing temperature at constant density. The measured solubilities were correlated using a semiempirical model.

Compounds

#	Formula	Name
1	CO2	carbon dioxide
2	C27H26N4O6	dibenzyl 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
3	C33H38N4O6	bis(4-phenylbutyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
4	C35H42N4O6	bis(5-phenylpentyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
5	C31H34N4O6	bis(3-phenylpropyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
6	C33H38N4O6	bis(3-(p-tolyl)propyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
7	C29H30N4O6	bis(2-phenylethyl) 2,6-dimethyl-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	1 2	Mole fraction - 2 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 2	spectrophotometer	16
POMD	1 3	Mole fraction - 3 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 3	spectrophotometer	21
POMD	1 4	Mole fraction - 4 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 4	spectrophotometer	21
POMD	1 5	Mole fraction - 5 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 5	spectrophotometer	21
POMD	1 6	Mole fraction - 6 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 6	spectrophotometer	24
POMD	1 7	Mole fraction - 7 ; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid Crystal - 7	spectrophotometer	21

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of Some Phenyl Derivatives of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(1-methyl-5-nitro-imidazol-2-yl)- 3,5-pyridinedicarboxylates in Supercritical Carbon Dioxide. Part II

Khajeh, M.[Mostafa], Yamini, Y.[Yadollah], Miri, R.[Ramin], Hemmateenejad, B.[Bahram]

ABSTRACT