Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of 11r-Hydroxy-16r,17r-Epoxyprogesterone in Different Solvents between 283 K and 323 K

nie, Q.[Qiang], Wang, J.-K.[Jing-Kang], Wang, Y.-l.[Yong-li], Wang, S.[Shi]
J. Chem. Eng. Data 2005, 50, 3, 989-992
ABSTRACT
The solubilities of 11R-hydroxy-16R,17R-epoxyprogesterone in methanol, ethanol, acetone, ethyl acetate, and acetic acid were measured using an isothermal method from 283 K to 323 K. A laser monitoring observation technique was used to determine the dissolution of the solid phase in a solid + liquid mixture. The solubility of 11R-hydroxy-16R,17R-epoxyprogesterone in the above solvents increased in the order ethanol < methanol < ethyl acetate < acetone < acetic acid. The experimental solubility data was correlated with a semiempirical equation.
Compounds
# Formula Name
1 C21H28O4 11.alpha.-hydroxy-16.alpha.,17.alpha.-epoxyprogesterone
2 CH4O methanol
3 C2H6O ethanol
4 C3H6O acetone
5 C4H8O2 ethyl acetate
6 C2H4O2 acetic acid
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • laser monitoring observation technique
  • 10
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • laser monitoring observation technique
  • 9
  • POMD
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • laser monitoring observation technique
  • 10
  • POMD
  • 5
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • laser monitoring observation technique
  • 10
  • POMD
  • 6
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • laser monitoring observation technique
  • 10