Hydrotropes enhance solubility of water-insoluble or sparingly soluble solutes such as o- and p-hydroxyacetophenones (HAPs) in aqueous solutions. The solubility of HAPs is experimentally determined in aqueous solutions of sodium cumene sulfonate (NaCS), sodium p-xylene sulfonate (NaXS), and sodium p-toluene sulfonate (NaPTS). The solubility of phenols increases almost by an order of magnitude at higher concentrations of the hydrotropes in the order NaPTS, NaXS, and NaCS, at a given temperature. The solubility o-HAP was twice that of p-HAP in the NaCS solutions, and a similar trend was observed in other hydrotrope solutions. The solubility data was fitted in the Association model of hydrotropy to estimate the hydrotrope-hydrotrope and hydrotrope-solute interaction parameters. NaCS, the more hydrophobic hydrotrope, shows stronger interaction with the phenols and a higher association constant.
Compounds
#
Formula
Name
1
C8H8O2
1-(2-hydroxyphenyl)ethanone
2
C8H8O2
4'-hydroxyacetophenone
3
C7H7NaO3S
sodium p-toluenesulfonate
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.