Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

Duarte, A. R. C.[Ana Rita C.], Coimbra, P.[Patricia], de Sousa, H. C.[Herminio C.], Duarte, C. M. M.[Catarina M. M]
J. Chem. Eng. Data 2004, 49, 3, 449-452
ABSTRACT
Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.
Compounds
# Formula Name
1 C15H13FO2 2-(2-fluoro-4-biphenylyl)propanoic acid
2 C2H6O ethanol
3 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal 1 - 1
  • OTHER
  • 27
  • POMD
  • 2
  • 3
  • 1
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Solvent: Mole fraction - 2; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • OTHER
  • 5