Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubilities of the Drugs Benzocaine, Metronidazole Benzoate, and Naproxen in Supercritical Carbon Dioxide

Garmroodi, A.[Aziz], Hassan, J.[Jalal], Yamini, Y.[Yadollah]
J. Chem. Eng. Data 2004, 49, 3, 709-712
ABSTRACT
The solubilities of the drugs benzocaine, metronidazole benzoate, and naproxen in supercritical carbon dioxide were measured at pressures ranging from (122 to 355) bar and temperatures ranging from (308 to 348) K. These drugs have mole fraction solubilies between 1.0 ? 10-5 and 1.2 ? 10-2, which are high enough to make the supercritical impregnation process a feasible alternative to impregnation employing organic solvents. Crossover pressures of (150, 180, and 150) bar were found for benzocaine, metronidazole benzoate, and naproxen, respectively. The solubility data were correlated with a semiempirical model.
Compounds
# Formula Name
1 C9H11NO2 ethyl 4-aminobenzoate
2 C14H14O3 (S)-(+)-naproxen
3 C13H13N3O4 metronidazole benzoate
4 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 4
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • Chromatography
  • 40
  • POMD
  • 4
  • 2
  • Mole fraction - 4 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • Chromatography
  • 40
  • POMD
  • 4
  • 3
  • Mole fraction - 4 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 3
  • Chromatography
  • 40