The poorly water-soluble anti-inflammatory rofecoxib is studied for solubility enhancement with the help of cosolvents such as methanol and ethanol as well as an anionic surfactant sodium lauryl sulfate (SLS) in water. The analysis of the drug is carried out by UV spectral measurements at max of 285 nm. The effect of mass fraction of cosolvents and surfactant on the solubility of the drug is studied at (298.15, 303.15, and 308.15) K. Increased solubility of rofecoxib was observed by increasing the mass fraction of methanol and SLS in water at all the temperatures. In the case of the water + ethanol mixture, the solubility of rofecoxib was somewhat unusual; that is, solubility increased with increasing mass fraction of ethanol up to 80%, but solubility decreased in pure ethanol at all the temperatures. Experimental solubility data of rofecoxib were correlated with those calculated by a log-linear equation.
Compounds
#
Formula
Name
1
C17H14O4S
rofecoxib
2
CH4O
methanol
3
C2H6O
ethanol
4
H2O
water
5
C12H25NaO4S
sodium dodecyl sulfate
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.