Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of the Drugs Bisacodyl, Methimazole, Methylparaben, and Iodoquinol in Supercritical Carbon Dioxide

Asghari-Khiavi, M.[Mehdi], Yamini, Y.[Yadollah]
J. Chem. Eng. Data 2003, 48, 1, 61-65
ABSTRACT
Fluids have been used before for the extraction and chromatography of drugs, but only a few literature references are available on drug solubility in supercritical fluids. The objective of this work concerned the experimental determination of the equilibrium solubilities of four compounds used as drugs (bisacodyl, methimazole, methylparaben, and iodoquinol) in supercritical carbon dioxide at temperatures ranging from (308 to 348) K and pressures from (122 to 355) bar. The measurements were performed using a simple and reliable static method. Iodoquinol showed solubilities below the range in which reliable data can be obtained with the used method. Bisacodyl, methimazole, and methylparaben solubilities were successfully correlated using a semiempirical model. Correlation of the results shows good self-consistency of the data obtained. Crossover pressures were observed for all compounds.
Compounds
# Formula Name
1 C8H8O3 methyl 4-hydroxybenzoate
2 C22H19NO4 4,4'-(2-pyridylmethylene)bisphenol diacetate
3 C4H6N2S imidazole-2-thiol, 1-methyl-
4 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 4
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • OTHER
  • 40
  • POMD
  • 4
  • 2
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • OTHER
  • 39
  • POMD
  • 3
  • 4
  • Mole fraction - 3 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 4
  • OTHER
  • 39