Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The equilibrium solubility of phenformin in 14 solvents of N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidinone (NMP), dimethyl sulfoxide (DMSO), methanol, isopropanol, ethanol, n-propanol, 1,4-dioxane, n-butanol, isobutanol, acetonitrile, ethyl acetate, ethylene glycol (EG), and water was gained using the saturation shake-flask method over a temperature range of 278.15 to 323.15 K under pressure p = 101.2 kPa. The mole fraction solubility of phenformin in the above neat solvents increased as the temperature increased and had a variation trend in the different solvents: DMF greater than DMSO greater than NMP greater than EG greater than methanol greater than ethanol greater than ethyl acetate greater than n-propanol greater than isopropanol greater than n-butanol greater than isobutanol greater than water greater than acetonitrile greater than 1,4-dioxane. It was correlated using the nonrandom two-liquid model, modified Apelblat equation, h equation, and the Wilson model. The obtained values of maximum root-mean-square deviation and relative average deviation gained via the four models were, respectively, 29.14 * 10 4 and 4.46 * 10 2. Also, the reduced excess enthalpy, activity coefficient under infinitesimal concentration, and mixing properties were derived based on the determined solubility data.