Thermodynamics Research Center, ThermoML : Journal of Chemical and Engineering Data

Measurements and Correlation of Water Activity in Aqueous Solutions Containing Diphenhydramine-Hydrochloride Drug, (D+)-Galactose, (D-)-Fructose, (D+)-Lactose, and Sucrose at 298.15 K

Majdan-Cegincara, R.[Roghayeh], Zafarani-Moattar, M. T.[Mohammed Taghi]
J. Chem. Eng. Data 2019, 64, 12, 5671-5680
ABSTRACT
Water activity in aqueous solutions containing diphenhydramine-hydrochloride, DPH-HCl, (D+)galactose, (D-)-fructose, (D+)-lactose and sucrose was measured using an improved isopiestic method at T=298.15 K. Vapor pressure values were calculated from the measured water activity data. NRTL, NRF-NRTL, mNRTL, Wilson, TNRF-mNRTL and modified NRTL proposed by Xu et al. local composition based models were applied for correlating the water activity data for binary and ternary aqueous solutions containing DPH-HCl drug and saccharides considered in this work. All of these models satisfactorily predicted the water activity data for the systems investigated. Water activity data and vapor pressure decreasing were utilized to highlight the solute-solvent interactions.
Compounds
# Formula Name
1 C17H22ClNO 2-diphenylmethoxy-N,N-dimethylethanamine hydrochloride
2 C6H12O6 D-fructose
3 C6H12O6 (+)-galactose
4 C12H22O11 4-O-.beta.-D-galactopyranosyl-D-glucose
5 C12H22O11 D-sucrose
6 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 3
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 1; Liquid
  • Molality, mol/kg - 3; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 36
  • POMD
  • 1
  • 2
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 1; Liquid
  • Molality, mol/kg - 2; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 32
  • POMD
  • 1
  • 4
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 1; Liquid
  • Molality, mol/kg - 4; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 36
  • POMD
  • 1
  • 5
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 1; Liquid
  • Molality, mol/kg - 5; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 32
  • POMD
  • 1
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 1; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 34
  • POMD
  • 3
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 3; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 9
  • POMD
  • 2
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 2; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 8
  • POMD
  • 4
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 4; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 9
  • POMD
  • 5
  • 6
  • (Relative) activity - 6 ; Liquid
  • Molality, mol/kg - 5; Liquid
  • Temperature, K; Liquid
  • Liquid
  • Gas
  • ISOPIE
  • 8