Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of drugs and pharmaceutical compounds in solvents and their mixtures are used in separation and purification in the chemical industries. In this work, the solid-liquid equilibria measurements for solubility of cetirizine hydrochloride (CTZ) and deferiprone in five single pure solvents as acetonitrile, ethanol, acetic acid, sulfolane and ethyl acetate, and their binary mixture, including ethanol + ethyl acetate, acetonitrile+ethanol, acetonitrile+acetic acid, and acetonitrile+sulfolane were measured at temperatures of 283.15 to 323.15 K and atmospheric pressure. The mole fraction solubility of both pharmaceuticals in all mono-solvents is enhanced by an increase in temperature. In addition, two empirical equations of modified Apelblat and h, and three local composition models of Wilson, NRTL, and UNIQUAC were employed to correlate the measured solubility data. The UNIQUAC model and modified Apelblat equation showed the most proper functions that could be used to correlate the solubility data for the present pure and mixed solvent systems, respectively.