Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of 3-hydroxy-2-nitropyridine in ten pure solvents and two binary mixture solvent (tetrahydrofuran + n-hexane and tetrahydrofuran + isopropanol) was measured from 278.15 K to 318.15 K. The solubility order in pure solvents was tetrahydrofuran greater thanacetone greater than acetonitrile greater than ethyl acetate greater thanmethanol greater than ethanol npropanol greater than isopropanolgreater than water greater than n-hexane. We used two models to fit monocomponent data and three binary mixed models to fit binary mixture solvent. For modified Apelblat model and h model, the maximum ARD values were 1.16% and 1.52%, respectively, and the maximum RMSD values were 1.61%, and 1.53%, respectively. For the Apelblat-Jouyban-Acree model, Jouyban-Acree model, and van't Hoff-Jouyban-Acree model, the maximum value of ARD is 3.69%, and the maximum value of RMSD is 0.48%. These models can fit the measured data well. We also discussed the effect of the interaction between solvent and solute on solubility. These experimental data are helpful for technological research and drug purification production.