Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this research, solubility of L-tryptophan in water, methanol, ethanol, acetone, isopropanol, n-butanol, acetonitrile, ethyl acetate, organic pure solvent and in three binary mixed solvents (water + acetonitrile), (water + methanol) and (water + isopropanol) at temperature range of T = (278.15 to 333.15) K with gravimetric method. The experimental results show that the solubility of L-tryptophan in above solvents increased as temperature rose, and it achieved highest dissolution efficiency in water. The improved Apelblat model, Buchowski-Ksiazaczak h model, van't Hoff model, Redlich-Kister (CNIBS / R-K) model and Jouyban-Acree model were used to nonlinearly fit the experimental data of solubility, and the consistency was good. The physicochemical information of L-tryptophan provided in this report may be helpful for its extraction/separation, recrystallization, and purification and formulation development.