Thermodynamics Research Center, ThermoML : Journal of Chemical and Engineering Data

Determination of the Solubility of the Repaglinide Drug in Supercritical Carbon Dioxide: Experimental Data and Thermodynamic Modeling

Sodeifian, G.[Gholamhossein], Hazaveie, S. M.[Seyed Mojtaba], Sajadian, S. A.[Seyed Ali], Ardestani, N. S.[Nedasadat Saadati]
J. Chem. Eng. Data 2019, 64, 12, 5338-5348
In the recent few years, the measurement, correlating, and calculation of solid solubility, especially drugs, in supercritical fluids have been increased. To produce micro-or nano-sized particles of a solid solute drug, it is vital to cheek its solubility behavior in supercritical carbon dioxide (SC-CO2). In this study, for the first time, the solubility of Repaglinide (RPL, antidiabetic drug) in SC-CO2 was determined using the static method. For this purpose, experiments were fulfilled at different operating temperatures (308-338 K) and pressures (120-270 bar). It was found that the solubility of RPL is within the range of 2.899 x 10-6 to 9.529 x 10-5 based on the mole fraction. Various methods were applied to correlate the solubility data of RPL, including equations of state (EoS), namely Peng-Robinson (PR), UNIQUAC model and six density-based semi-empirical models, namely Sodeifian et al., Chrastil, Bartle et al., Garlapati and Madras, Mendez-Santiago and Teja (MST), and Kumar and Johnston (K-J). Moreover, self-consistency tests were carried out to discover the RPL solubility in SC-CO2. Finally, the approximate values of total (), vaporization (), and solvation () enthalpies were computed.
# Formula Name
1 C27H36N2O4 repaglinide
2 CO2 carbon dioxide
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 2
  • Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 1
  • UV spectrometry
  • 24