Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In the recent few years, the measurement, correlating, and calculation of solid solubility, especially drugs, in supercritical fluids have been increased. To produce micro-or nano-sized particles of a solid solute drug, it is vital to cheek its solubility behavior in supercritical carbon dioxide (SC-CO2). In this study, for the first time, the solubility of Repaglinide (RPL, antidiabetic drug) in SC-CO2 was determined using the static method. For this purpose, experiments were fulfilled at different operating temperatures (308-338 K) and pressures (120-270 bar). It was found that the solubility of RPL is within the range of 2.899 x 10-6 to 9.529 x 10-5 based on the mole fraction. Various methods were applied to correlate the solubility data of RPL, including equations of state (EoS), namely Peng-Robinson (PR), UNIQUAC model and six density-based semi-empirical models, namely Sodeifian et al., Chrastil, Bartle et al., Garlapati and Madras, Mendez-Santiago and Teja (MST), and Kumar and Johnston (K-J). Moreover, self-consistency tests were carried out to discover the RPL solubility in SC-CO2. Finally, the approximate values of total (), vaporization (), and solvation () enthalpies were computed.