Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of marbofloxacin in 12 pure solvents (methanol, ethanol, isopropanol, n-propanol, n-butanol, tert-amyl alcohol, acetonitrile, ethyl acetate, acetone, toluene, tetrahydrofuran, and 1,4-dioxane) at T = 283.15 to 328.15 K and P = 101.3 kPa was measured by a dynamic laser monitoring method. Results of these experiments demonstrate that the solubility of marbofloxacin in those 12 pure solvents increased with the increase of temperature. The experimental results showed that the solubility of marbofloxacin in the pure solvents decreased in the order of tetrahydrofuran greater than acetone greater than ethyl acetate greater than methanol acetonitrile (before 305.30 K) or greater than methanol acetonitrile greater than ethyl acetate (behind 305.30 K) greater than 1,4-dioxane greater than n-butanol greater than n-propanol greater than ethanol greater than tert-amyl alcohol greater than isopropanol greater than toluene. The Apelblat model, h model, and nonrandom two-liquid (NRTL) model were used to correlate with the experimental solubility data. Compared with the h model and NRTL model, the Apelblat model has a better correlation with the experimental values. The experimental solubility data and the correlation model in this study can be helpful for the related scientific research and scale-up production.