Paeonol shows a wide range of pharmacological activities in the pharmaceutical industries. In this study, the solubility of paeonol in supercritical carbon dioxide (ScCO2) is determined by measuring the cloud-point pressures of the binary system in a high-pressure variable-volume view cell at various temperatures (i.e., 313.2 K 318.2 K, 323.2 K, 328.2 K, 333.2 K ) and pressure range of 8-15 MPa. The results show that paeonol has good solubility in ScCO2, and the solubility increases obviously with the decreasing temperature and the enhancing pressure in the experimental range. Then, four density-based models, named Bartle, Mendez-Santiago and Teja, Ch and Madras, and Gordillo are employed to correlate and predict the solubility data. The relevant AARD values of Bartle, Mendez-Santiago and Teja, Ch and Madras, and Gordillo are 9.05%, 9.37%, 8.75%, and 8.49%, respectively, indicating that the models can well predict the solubility data.
Compounds
#
Formula
Name
1
C9H10O3
1-(2-hydroxy-4-methoxyphenyl)ethan-1-one
2
CO2
carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.