Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this research, the solid-liquid equilibrium solubility of diclazuril was measured by isothermal saturation method and the influence of solvent effect on solubility was discussed. In mono-solvents, at the determined temperature, the solubility values of diclazuril decrease according to the order: DMF greater than acetone greater than acetonitrile greater than ethyl acetate greater than methanol greater than ethanol greater than 1-propanol greater than 2-propanol greater than 1-butanol greater than toluene. The solvent effect was discuss, from solvent effect, HBD interaction of the solvent with the solute and nonspecific dipolarity/polarizability interactions are favorable to dissolution, and the nonspecific dipolarity/polarizability interactions had a great contribution to the total solvent effect for the studied mono-solvents. Besides, in two binary solvent mixtures, the solubility increases with the increasing ratio of DMF/acetone, and decrease with the increase of ethanol. What!|s more, five models including modified Apelblat equation, Uh equation, Jouyban-acree model, van!|t Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model were used to correlate the diclazuril solubility in mono-solvents and binary solvent mixtures systems, respectively. The RAD and RMSD values were not exceeding 0.97% and 6.95 e10-4, respectively. These all five models can correlate the solubility values of diclazuril very well. Ultimately, the experimental data presented in this study can provide basic data for improving the solubility of diclazuril.