Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The experimental determination of D-aspartic acid solubility in water and organic solvents such as N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), 1.4-dioxane, ethylene glycol (EG), acetone, ethanol, n-propanol, methanol, isopropanol and n-butanol was made via the shake flask technique. The experiments were carried out from 288.15 K to 333.15 K under ambient pressure p = 101.2 kPa. Values of solubility for D-aspartic acid in the twelve solvents increased as the temperature rised. Highest mole fraction solubility value of D-aspartic acid was observed in DMF and NMP, and lowest, in n-butanol and isopropanol. The solubility values obeyed the order in different solvents: DMF (NMP) greater than DMSO greater than 1.4-dioxane greater than EG greater than acetone greater than water greater than methanol greater than ethanol greater than n-propanol greater than n-butanol (isopropanol). The obtained solubility was described mathematically through the h equation and Apelblat equation. The largest percentage of average relative deviation was 2.6010-2; and the maximum root mean square deviation, 3.8910-4. Moreover, the degree and type of solvent-solute and solvent-solvent interactions were investigated through the linear solvation energy relationship analysis of solvent effect.