ABSTRACT

Abstract: The solubility of 2-oxindole in twelve pure organic solvents including acetonitrile (MeCN), dichloromethane (DCM), 1,4-dioxane, ethyl acetate (EtOAc), acetone, toluene, methanol, ethanol, 2-propanol, tetrahydrofuran (THF), 1-butanol and 1-propanol, were experimentally measured from (283.15 to 358.15) K at normal pressure p = 0.1 MPa by employing the synthetic method. The measured solubilities of 2-oxindole in these pure organic solvents were found increasing with the rise of temperature. The experimental solubilities of 2-oxindole were correlated with several thermodynamic models including modified Apelblat equation, h (Buchowski) equation, Wilson equation and NRTL equation. These data could be applied for the large-scale synthesis of 2-oxindole with high purity.

Compounds

#	Formula	Name
1	C8H7NO	indolin-2-one
2	C2H3N	acetonitrile
3	CH2Cl2	dichloromethane
4	C4H8O2	1,4-dioxane
5	C4H8O2	ethyl acetate
6	C3H6O	acetone
7	C7H8	toluene
8	CH4O	methanol
9	C2H6O	ethanol
10	C3H8O	propan-2-ol
11	C4H8O	tetrahydrofuran
12	C4H10O	butan-1-ol
13	C3H8O	propan-1-ol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Triple point temperature, K ; Crystal 1			Crystal 1 Liquid Air at 1 atmosphere	DSC	1
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal 1			Crystal 1 Liquid Air at 1 atmosphere	DSC	1
POMD	1 2	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 1	Titration method	11
POMD	1 3	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 1	Titration method	7
POMD	1 4	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	11
POMD	1 5	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 1	Titration method	11
POMD	1 6	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 7	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 8	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 9	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 10	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 1	Titration method	9
POMD	1 11	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 12	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 1 - 1	Titration method	9
POMD	1 13	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal 2 - 1	Titration method	9

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility Measurement and Correlation of 2-Oxindole in 12 Pure Organic Solvents

Liu, J.-Q.[Jin-Qiang], Ji, L.[Li], Gao, Q.[Qi], Pan, H.-Y.[Hai-Yang], Feng, R.-X.[Rui-Xiang], Tang, Y.-F.[Yan-Fei]

ABSTRACT