Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Like the drug-salt interactions, drug-amino acid interaction in the aqueous medium is dependent upon different physiological events occurring in the body. In this context, investigations on the interactions of ciprofloxacin hydrochloride (CFX) being a secondgeneration antibiotic with both non-essential amino acid and essential amino acid have been done. The physico-chemical properties like apparent molar volume (V2,) and apparent molar isentropic compression (Ks,2,) of drug, CFX in water and in the presence of glycine (GLY) and L-isoleucine (ILU) at mB (molality of GLY or ILU) = 10, 20, 35, 50 and 75 mmol*kg-1 have been determined over the temperature range (288.15 to 323.15) K and at p = 1x105 Pa. These data have further been used to calculate different parameters which help to obtain valuable information corresponding to the distinct kinds of interactions present in the ternary systems. The volumes and compressibility studies data have shown that the predominant interactions are hydrophilic-hydrophilic and hydrophilic-ionic in the studied systems. It may be postulated that the effect of CFX prevails through the hydrophilic groups of the constituents of proteins. Dehydration behaviour of drug is also observed using hydration number and calorimetry at higher mB values. Both hyperchromic and hypsochromic changes have been observed from the absorption spectra for the CFX/ILU system.