Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of gastrodin in pure and mixed solvents was determined by using the isothermal saturation method at temperatures ranging from (273.15 to 313.15) K under 101.0 kPa. At all studied temperature, the solubility data obey the following order: 1,4-dioxane greater than ethyl acetate greater than toluene greater than cyclohexanone greater than isopropanol greater than acetone greater than ethanol greater than n-propanol greater than acetonitrile greater than 1-butanol greater than cyclohexane. In mixture of (ethyl acetate + ethanol), it increases firstly and then decreases with the increasing mass fraction of cosolvent. The composition dependence of the solubility has a maximum at around w = 0.8. The solubility data in pure and mixed solvents were correlated by modified Apelblat equation, h equation, Jouyban-Acree model and CNIBS/R-K model. In pure solvent, the largest RMSD value is 5.710-5, which is obtained in h equation, the RAD values are all less than 6.77%. In mixed solvents, the RAD data between the experimental and calculated values by Jouyban-Acree model is a little larger, 5.27%, and the RMSD value is 3.2210-4. However, with CNIBS/R-K model, the maximum RAD value obtained by the CNIBS/R-K model is 2.68% and the RMSD value is 7.110-5. CNIBS/R-K model is better