Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubilities of D-tryptophan in neat n-propanol, ethyl acetate, Page 2 of 23 ethylene glycol (EG), n-butanol, acetonitrile, 1-octanol and dimethyl sulfoxide (DMSO) and L-tyrosine in ethyl acetate, EG, isopropanol, acetonitrile, n-butanol and N,N-dimethylformamide (DMF) were determined via shake-flask method at temperatures from 283.15 K to 328.15 K under about 101.2 kPa. At the fixed temperature, the mole fraction solubility of D-tryptophan was largest in EG, and lowest in 1-octanol. However, for the L-tyrosine, the maximum solubility was observed in the solvent of ethyl acetate; and minimum, in n-butanol. X-ray power diffraction analysis was carried out to analyze the solids equilibrated with corresponding liquor, indicating that no polymorphic transformation or solvate formation took place in the studied systems. The solubility correlation was performed via the Apelblat equation. The obtained maximum root-mean-square deviation and relative average deviation were 2.74x10-5 and 0.68 %, respectively. In addition, the solvent-solvent and solute-solvent interactions were investigated on the basis of the approach of linear solvation energy relationship.