Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this paper, the solubility of hydrochlorothiazide was determined by using laser method in pure solvents (methanol, ethanol, n-propanol, isopropanol, acetonitrile, ethyl acetate, water, 2-butyl alcohol, 1-pentanol, isobutyl alcohol) and binary solvent mixtures of (methanol + water) and (acetonitrile + n-propanol) at the temperatures ranging from 283.15 to 323.15 K about 5 K intervals at atmospheric pressure. The solubility increases with the increasing of temperature in all pure solvents we chose. However, the solubility of HCT increases with increasing methanol content, and it increases first and then decreases with increasing acetonitrile content at constant temperature. The dissolving capacity of HCT ranks as methnol greater than acetonitrile greater than ethanol greater than ethyl acetate greater than n-propanol (isopropanol) greater than 2-butyl alcohol (isobutyl alcohol) greater than 1-pentanol greater than water. The experiment data were well-correlated with the modified Apelblat equation, h equation, NRTL equation and modified Jouyban-Acree model, respectively.