Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The determination of solubility of domperidon in aqueous cosolvent mixtures of isopropanol, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and ethanol was carried out by a shake-flask method over the temperatures from (293.15 to 333.15) K under local atmospheric pressure p = 101.1 kPa. As may be observed that the domperidone solubility increased and then decreased as the mass fractions of DMF (DMSO, isopropanol or ethanol) increased. The maximum solubility data was found with the cosolvent composition of 0.8 in mass fraction. The determined solubility values were correlated by using the Jouyban-Acree, van't Hoff-Jouyban-Acree and Apelblat-Jouyban-Acree models. The attained average relative deviations were smaller than 7.56 %. Preferential solvation analysis of domperidone was performed by the inverse Kirkwood-Buff integrals method. The preferential solvation parameters (x1,3) by the cosolvent showed positive in the composition regions of 0.20 less than x1 less than 0.50 for DMF, 0.24 less than x1 less than 0.55 for isopropanol, 0.20 less than x1 less than 0.45 for DMSO and 0.24 less than x1 less than 0.61 for ethanol. Domperidone was solvated preferentially by the cosolvents in the regions. We may conjecture that the drug acts as a Lewis acid in front of isopropanol (DMF, DMSO and ethanol) molecules.