Propylthiouracil Solubility in Aqueous Solutions of Ethylene Glycol, N,N-Dimethylformamide, N-Methyl-2-pyrrolidone, and Dimethylsulfoxide: Measurement and Thermodynamic Modeling
Solubility values of propylthiouracil dissolved in four neat solvents of N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), ethylene Glycol (EG) and dimethylsulfoxide (DMSO) and aqueous cosolvent mixtures of DMF (1) + water (2), NMP (1) + water (2), EG (1) + water (2) and DMSO (1) + water (2) at temperature range from (293.15 to 333.15) K was reported. The determination was made by using the saturation shake-flask method under 101.1 kPa. At the same composition of DMF, NMP, EG or DMSO and temperature, the mole fraction solubility of propylthiouracil was highest in DMF (DMSO) (1) + water (2) mixtures, and lowest in EG (1) + water (2) mixtures. Using the Apelblat-Jouyban-Acree model, van't Hoff-Jouyban-Acree model, and Jouyban-Acree model, propylthiouracil solubility was well correlated acquiring relative average deviation lower than 3.01 % and root-mean-square deviation lower than 9.7510-4.
Compounds
#
Formula
Name
1
C7H10N2OS
6-propyl-2-thiouracil
2
C3H7NO
dimethylformamide
3
C5H9NO
N-methylpyrrolidone
4
C2H6O2
1,2-ethanediol
5
C2H6OS
dimethyl sulfoxide
6
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.