Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Solid-liquid equilibrium measurements for systems of posaconazole ((4-[4-[4-[4-[[(5~{R})-5(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl) oxolan-3-yl]methoxy]phenyl] piperazin-1yl]phenyl]-2-[(2~{S},3~{S})-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one)) and voriconazole ((2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan- 2-ol) in 10 pure solvents was determined by equilibration and subsequent analysis by differential thermal with thermal gravimetry analysis (DTA/TGA) within the temperature limits T = (278.2 to 323.2) K at a pressure of 0.101 MPa. The temperatures and heats of fusion of the solutes were also measured by DTA/TGA. The maximum solubility for posaconazole and voriconazole was in dimethyl sulfoxide at T = 323.2 K. The minimum solubilities were in water at T = 278.2 K. In all the measured systems, the solubility increases nonlinearly with temperature. The solubility data was successfully correlated using the Non-Random TwoLiquid model and the modified Apelblat equation.