Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The equilibrium solubility of bifonazole in solvent mixtures of methanol (1) + water (2), n-propanol (1) + water (2), isopropanol (1) + water (2) and propylene glycol (1, PG) + water (2) was determined experimentally by using isothermal dissolution equilibrium method within the temperature ranging from (278.15 to 318.15) K under atmospheric pressure (101.1 kPa). The solubility of bifonazole increased monotonously with the increase in mass fraction of methanol, n-propanol, isopropanol and PG and temperature. At the same temperature and mass fraction of methanol (n-propanol, isopropanol and PG), the mole fraction solubility of bifonazole is greater in (methanol + water) than in the other three solvent mixtures. Besides, the solubility of bifonazole was correlated with the Jouyban-Acree model, van't Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model. The obtained average relative deviations lower than 4.75 % for correlative studies. It is noteworthy that the solubility data presented in this work contribute to expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution.