ABSTRACT

The solubility of Mifepristone in eight pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, propanone, ethyl acetate, tetrahydrofuran and mixed solvents of water + methanol have been experimented at 273.15 to 318.15 K by using an experimental method of High Performance Liquid Chromatography (HPLC). The solubility data in eight pure solvents was correlated by the modified Apelblat equation, Van't Hoff equation, h equation, NRTL equation, UNIQUAC equation, and Wilson equation. The solubility data in the mixed solvents of water + methanol was correlated by the modified Apelblat equation, Van't Hoff equation, h equation, NRTL equation, UNIQUAC equation, Jouyban-Van't Hoff equation and Jouyban-Apelblat equation. The solubility of the Mifepristone in eight pure solvents and mixed solvents increased as the temperature increased. The calculated values by using the modified Apelblat equation, Van't Hoff equation, h equation, NRTL equation, UNIQUAC

Compounds

#	Formula	Name
1	C29H35NO2	mifepristone
2	CH4O	methanol
3	C2H6O	ethanol
4	C3H8O	propan-1-ol
5	C3H8O	propan-2-ol
6	C4H10O	butan-1-ol
7	C3H6O	acetone
8	C4H8O2	ethyl acetate
9	C4H8O	tetrahydrofuran
10	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Triple point temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1 2	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 3	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 4	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 5	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 6	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 7	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 8	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 9	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	10
POMD	1 2 10	Mole fraction - 1 ; Liquid	Solvent: Mass fraction - 10; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	gravimetric	100

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Measurement and Correlation of the Solubility of Mifepristone in Eight Pure and Water + Methanol Mixed Solvents at Temperatures from 273.15 to 318.15 K

Xu, Juan, Li, Peng, Chen, Xiaofeng, Wang, Huiping, Ning, Lifeng

ABSTRACT