Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The equilibrium solubility is the basis of purification and further theoretical studies of biapenem. In this work, The solubility of biapenem in ten pure solvents (methanol, ethanol n-propanol, isopropanol, acetone, N,N-dimethylformamide (DMF), acetonitrile, dimethyl sulfoxide (DMSO), N-methyl pyrrolidone (NMP) and ethyl acetate) and solvent mixtures (ethyl acetate + methanol) was measured by using a static equilibrium method at temperatures from 283.15 K to 323.15 K, at p = 101.2 kPa. To sum up, the solubility was highest in NMP and lowest in acetone. the solubility from high to low is: NMP (0.9663x10-4, 298.15K) greater than DMSO (0.8655x10-4, 298.15K) greater than DMF (0.7796x10-4, 298.15K) greater than ethyl acetate (0.7161x10-4, 298.15K) greater than acetonitrile (0.5169x10-4, 298.15K) greater than methanol (0.3068x10-4, 298.15K) greater than ethanol (0.2455x10-4, 298.15K) greater than n-propanol (0.1966x10-4, 298.15K) greater than isopropanol (0.1205x10-4, 298.15K) greater than acetone(0.04576x10-4, 298.15K). The experiment values in monosolvents were associate with modified Apelblat equation; The experiment