Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of warfarin sodium isopropanol solvate (WS IPA), a widely used anticoagulant, was determined at temperatures ranging from 278.15 to 333.15 K in four pure solvents (acetone, ethanol, isopropanol, water), five binary solvent mixtures (isopropanol + acetone, isopropanol + ethanol, isopropanol + water, isopropanol + heptane, isopropanol + hexane), and five ternary solvent mixtures (isopropanol + acetone + heptane, isopropanol + acetone + hexane, isopropanol + ethanol + heptane, isopropanol + ethanol + hexane, isopropanol + water + heptane) using the polythermal method. It was demonstrated that the solubility of WS IPA increases with increasing temperature in the pure solvents and at constant solvent composition in the solvent mixtures. In addition, the solubility of WS IPA in isopropanol increases with increasing content of acetone, ethanol and water, which act as co-solvents and decreases with increasing content of heptane and hexane, which act as anti-solvents. The experimental solubility data of WS IPA in pure solvents, binary, and ternary solvent mixtures was correlated using the modified Apelblat and h model equations. The correlated solubility data agree with the experimental data based on the relative deviation (RD) and the average relative deviation (ARD%) values. Thus, the correlated