Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of gatifloxacin in twelve pure solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, acetone, butanone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene and N,N-dimethylformamide (DMF) was determined by using a isothermal saturation method with temperatures ranging from (273.15 to 318.15) K. The results show that the solubility of gatifloxacin in those twelve pure solvents increases with increasing temperature. At a given temperature range, they gradually decrease in the following order: ethyl acetate greater than DMF greater than butanone greater than acetonitrile greater than n-butanol greater than acetone greater than 1,4-dioxane greater than n-propanol greater than ethanol greater than methanol greater than isopropanol greater than toluene. The (KAT-LSER) model was applied to analyze the effect of the solute-solvent intermolecular interactions on the solubility in those pure solvents. Moreover, the obtained solubility data were correlated with the modified Apelblat equation, h equation. The correlation showed good agreement with experimental