Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility data of probenecid in twelve different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n-propanol, n-butanol, butyl acetate, n-pentanol, isopropanol, isobutanol, acetone and methyl tert-butyl ether was measured using gravimetric method over the temperatures range from 283.15 K to 323.15 K at 0.1 MPa. The acetone showed a far higher solubility to probenecid than other solvents. Three models including modified Apelblat equation, van t Hoff model, and Non-random two liquid (NRTL) model were applied to correlate the measured solubility data. The correlation results were evaluated by the average relative deviation (ARD). All the ARD values was less than 4.522%, which indicated that the three models have a satisfactory correlation. The mixing thermodynamics properties of probenecid in twelve pure organic solvents including mixing enthalpy, mixing Gibbs energy and mixing entropy were calculated by NRTL model using the correlation results.