Vitamin E acetate (VEA) has been widely used as medicines, nutrients, and cosmetic additives. The solubility data are the basis for designing the processes of the relative VEA dosage form preparation. In this study, the static cloud-point method is employed to determine the solubility of VEA in supercritical carbon dioxide (scCO2) with ethanol (0.5, 1 and 2 mol%) as the cosolvent at temperatures of 313.15, 318.15, 323.15, and 328.15 K, and pressures of 8-15 MPa. The results show that the solubility of VEA in scCO2 can be remarkably enhanced by adding ethanol as the cosolvent. It could also be increased with the enhancing pressure and the decreasing temperature at the constant ethanol concentration. Furthermore, four semi-empirical models including Christil-G, K-J, Bartle, and MST-S are employed to correlate the experimental data. The AARD values of these models range from 2.43 to 6.86%, indicating that these models could well predict the VEA solubility data in scCO2 + ethanol systems of this study.
Compounds
#
Formula
Name
1
C31H52O3
DL-.alpha.-tocopherol acetate
2
C2H6O
ethanol
3
CO2
carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.