Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this work, the solid-liquid equilibrium for levetiracetam in ten neat solvents (methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene and cyclohexane) and binary liquid mixtures (ethanol + ethyl acetate) was measured by using a static gravimetric method at temperatures T = (283.15 to 323.15) K under pressure of 101.2 kPa. In general, the equilibrium solubility was highest in methanol and lowest in cyclohexane. The solubility values in neat solvents were correlated by the modified Apelblat equation, h equation, Wilson model and NRTL model; and in the binary solvent mixtures, by three cosolvency models including Jouyban-Acree model, van't Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model. Compared with the results of above models, the calculated solubility provided good results with the experimental data. Consequently, for the monosolvents, the maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 9.91x10-4 and 2.50 %, respectively; and for the binary solvent mixtures, 2.75x10-4 and 0.80 %. Furthermore, the ACS Paragon Plus Environment