Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Glibenclamide (GCM) is an oral anti-hyperglycemic drug and widely used to treat type - II diabetes. The quality of the GCM product impacts the efficacy of the medicine. However, the quality of the product is determined by the crystallization process, in which the solubility property plays a significant role. In this study, GCM solubility in eleven pure solvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, acetonitrile, methyl isobutyl ketone, methyl acetate and ethyl acetate) and (acetone + acetonitrile) binary solvents, has been determined through a gravimetric method from 283.15 K to 323.15 K. It elucidates that GCM has highest solubility in acetone among the eleven mon-solvents. Meanwhile, in (acetone + acetonitrile) binary solvents, the solubility of GCM increases when the mole fraction of acetone rises. Then, we correlated the solubility data in mono-solvents using modified Apelblat model and NRTL model. Besides, the modified Apelblat model, CNIBS/R-K model, Jouyban-Acree model and NRTL model were adopted to fit the data in (acetone + acetonitrile) mixture solvents. Furthermore, thermodynamic properties were calculated on the basic of the NRTL model.