ABSTRACT

The effect of 1-hexyl-3-methylimidazolium salicylate, [HMIm][Sal] as an ionic liquid form of active pharmaceutical ingredient (API-IL) on the thermodynamic behavior of two simple amino acids, glycine and L-alanine have been investigated. The densities, speeds of sound, viscosities and refractive indices of the amino acids in the mixtures of ([HMIm][Sal] + water) have been determined at T=298.15 K. Moreover, the electrical conductivities of the studied API-IL have been measured in water, and aqueous mixtures of the amino acids at T=298.15 K. The measured data were utilized to compute the partial molar volume of transfer ( traV0 ), partial molar isentropic compressibility of transfer ( tra ), viscosity B-coefficient of transfer (traB), ion association constant (KA) and molar refraction (RD) quantities. The increase in the positive values of traV0 , tra

Compounds

#	Formula	Name
1	C2H5NO2	2-aminoacetic acid
2	C3H7NO2	(S)-2-aminopropanoic acid
3	C17H24N2O3	1-hexyl-3-methylimidazolium salicylate
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 3 4	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	24
POMD	1 3 4	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Single path-length method	24
POMD	1 3 4	Viscosity, Pa*s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	24
POMD	1 3 4	Refractive index (Na D-line) ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	24
POMD	1 3 4	Molar conductivity, S*m2/mol ; Liquid	Solvent: Molality, mol/kg - 1; Liquid Molality, mol/kg - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Alternating current cell with electrodes	53
POMD	2 3 4	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	24
POMD	2 3 4	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Single path-length method	24
POMD	2 3 4	Viscosity, Pa*s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	24
POMD	2 3 4	Refractive index (Na D-line) ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Molality, mol/kg - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	24
POMD	2 3 4	Molar conductivity, S*m2/mol ; Liquid	Solvent: Molality, mol/kg - 2; Liquid Molality, mol/kg - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Alternating current cell with electrodes	50
POMD	3 4	Molar conductivity, S*m2/mol ; Liquid	Molality, mol/kg - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Alternating current cell with electrodes	13

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Thermophysical Properties of 1-Hexyl-3-methylimidazolium Salicylate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) in Aqueous Solutions of Glycine and l-Alanine

Shekaari, Hemayat, Zafarani-Moattar, Mohammed Taghi, Mirheydari, Seyyedeh Narjes, Faraji, Saeid

ABSTRACT