Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Solubility of nicotinamide in a series of pure solvents, including water, ethanol, 1-propanol, isopropanol, ethyl acetate, methanol, 1-butanol, methyl acetate, isobutanol, acetone and butyl acetate has been measured between 283.15 K and 323.15 K. The data increases with rising of temperature, and mainly follows the order: methanol greater than ethanol greater than 1-propanol greater than isopropanol greater than 1-butanol greater than isobutanol greater than acetone greater than methyl acetate greater than ethyl acetate greater than butyl acetate greater than water. The experimental data in different solvents was well correlated by NRTL equation, Wilson equation and modified Apelblat equation. To further study above dissolution behavior, the thermodynamic properties, including dissolution Gibbs energy, dissolution entropy and dissolution enthalpy were also calculated. Based on solubility data, ethanol was selected as cocrystallization solvent for nicotinamide and benzoic acid, and one cocrystal product was firstly formed and characterized.