Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of imatinib mesylate in nine mono-solvents and two binary solvents was determined by the shaken flask method followed by UV composition analysis from 278.15 K to 318.15 K at atmospheric pressure. The solubility increases with the increase of temperature in all solvents we chose. Meanwhile, the dissolving capacity of imatinib mesylate ranks as methyl acetate less than 2-propanol less than acetonitrile less than isobutanol less than 1-butanol less than tetrahydrofuran less than 1-propanol less than ethanol less than methanol. The Apelblat model, h equation and NRTL model described the solubility data of imatinib mesylate in mono-solvents, simultaneously, the Apelblat model, CNIBS/R-K model and NRTL model were employed in binary solvents. The results show a satisfactory correlation with the experimental data. Additionally, mixing thermodynamic properties of imatinib mesylate were calculated based on the NRTL model, which reveals the mixing process is spontaneous and exothermic.