Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Solubilities of five organic semiconductors and four non-steroidal anti-inflammatory drugs (NSAIDs) were measured by a static analytical method in a set of seven representative organic solvents at 298.15 K and 0.10 MPa to determine the Hansen solubility parameter (HSP) of the solutes by a quantitative correlation with the extended Hansen model. Solubilities of the organic semiconductors (N,N'-di-1-naphthyl-N,N'-diphenylbenzidine (NPB), 4,4'-bis(9H-carbazol-9-yl)biphenyl (CBP), anthracene, tetracene, and perylene) exhibited similar solvent dependence to each other, increasing in the order of ethanol less than acetonitrile less than hexane less than acetone less than carbon tetrachloride less than chlorobenzene chloroform due to the large dispersion parameter D 21 and the small polarity and hydrogen bonding parameters (P, H) (5, 5) of the solutes. In contrast, the solubilities of NSAIDs (naproxen, diclofenac, indomethacin, and niflumic acid) were hexane less than carbon tetrachloride less than acetonitrile chlorobenzene less than ethanol chloroform less than acetone, indicating the smaller D 19 and the larger (P, H) (10, 11). The HSP analysis enabled us to estimate the solubilities in other solvents and solvent mixtures; e.g., solubility maximum of indomethacin in the mixtures of ethanol with ethyl acetate, acetone, and acetonitrile was well described by the minimum Hansen distance.