Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Experimental allopurinol solubility in water and 14 organic solvents namely N,N-dimethylformamide (DMF), isopropanol, ethanol, methanol, acetone, acetonitrile, n-propanol, n-heptanol, 1-hexanol, n-butanol, 2-butanone, N-methyl-2-pyrrolidone (NMP), 1.4-dioxane, cyclohexane has been studied by using a method of shake-flask. The experiments were carried out over the temperature range from 278.15 to 333.15 K under p=101.2 kPa. The solubility of allopurinol in selected solvents raised with the rise in temperature. The solubility values of allopurinol were recorded as maximum in NMP and minimum in cyclohexane. The obtained solubility data was mathematically described with the h equation, Apelblat equation and NRTL equation. The maximum percentage of average relative deviation was 1.73x10-2; and the maximum value of root mean square deviation, 2.416x10-4. Furthermore, solvent effect was analyzed through the method of SERL (Linear Solvation Energy Relationship). The extent and type of solvent-solute and solvent-solvent interactions was recognized.