Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The object is to research the solid-liquid phase of enalapril maleate and its intermediate enalapril hydride in pure solvent. Within the investigated temperature range, the mole fraction solubility data in the selected solvents increase with the increasing temperature. The solubility of enalapril hydride in different solvents decrease according to the following order: ethyl acetate greater than acetone greater than ethanol greater than n-octanol greater than isopropanol greater than acetonitrile; while enalapril maleate obey the order: ethyl acetate greater than acetone greater than ethanol greater than acetonitrile greater than n-octanol greater than isopropanol. The experimental solubility data of enalapril hydride and enalapril maleate in those solvents were correlated by the modified Apelblat equation, Buchowski-Ksiazaczak h equation and Wilson equation. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) obtained by the three equations were 1.48x10-4, 4.12% (enalapril hydride) and 2.82x10-4, 4.99% (enalapril maleate) respectively. It was found from the RMSD value that the modified Apelblat equation is more ACS Paragon Plus Environment